Edit: It’s for NTSC compatible Nintendo 3DS.
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I guess only compatible with US 3DS devices.
it’s super easy to jailbreak a 3ds now, worth it just to remove the stupid region lockout. 3ds dot hacks dot guide has a super simple step by step idiot proof guide on how to install the jailbreak which turns off the region lockout
From the Limited Run’s site: "Shantae and the Pirate’s Curse is on a physical cartridge for NTSC compatible Nintendo 3DS. "