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Joined 11 months ago
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Cake day: October 12th, 2023

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  • Generations aren’t about hard lines of division. For example, if some was born in December 1979 and another in January 1980, they would have more in common than with someone born in 1975 or 1985.

    I was born six months before the millennial cutoff, but I find many of my touchstones align with millennials than with Gen X and then I have some that line up with Gen X.

    Ultimately, the utility of generational analysis is degraded with pieces like this. There seems to be something useful about looking at how certain aged people relate to events, but trying to ask about “How millennials are ruining the work place for Gen X” isn’t a good use of that analysis.






  • Again, and I can’t emphasize this enough, this is not my area of study and seems like you have better handling of the subject. But when I read his quote, this part sticks out to me:

    much of the exquisite control over these proteins is held offstage, nested within the noncoding junk.

    Additionally, the article calls into question the role of code and protein production as the only role for DNA.

    Still other noncoding stretches may be buffers against precipitous change, serving rather as flak jackets to absorb the impact of viruses and other genetic interlopers that infiltrate an animal’s chromosomes. Without all the extra padding to absorb the blows, viruses or the bizarre genetic sequences that hop and skip from one part of the chromosome to another – mysterious genetic elements called transposons or jumping genes – might land smack in the middle of a crucial gene, disrupting its performance.

    So there maybe stretches of DNA that don’t participate in protein construction, but still has a role. So I question I idea of centering one type function over another.





  • Good enough for high school biology. But not when you’re doing influential cancer research. The following is from Subanima’s article on the same subject:

    One of the most influential papers in cancer biology published in 2000 was the “Hallmarks of cancer” by Douglas Hanahan and Robert Weinberg. It outlined six of the main capabilities of cancer and laid out a rough program for studying the disease ointo the 21st century. To date, it has over 39,000 citations which, in academia, is officially known as a shitton.

    It was so successful that they released a sequel in 2011 which has over 62,000 citations - also known as a metric shitton.

    But at the heart of both papers is the machine metaphor and the idea that if we just map out all the functions of proteins in one ginormous map, we’ll just have to run some maths and we’ll know everything we need to know to cure cancer. In 2000 they wrote:

    Two decades from now, having fully charted the wiring diagrams of every cellular signalling pathway, it will be possible to lay out the complete ‘integrated circuit of the cell.’

    He also notes the same thing you noted, that it’s a good metaphor for high schoolers.