Speaking Japanese honestly isn’t too hard. Reading/writing Japanese is more difficult but is easier as you realize the complex Kanji are just combinations of simpler kanji and how those relate to meaning. Most of the sounds are also in English.
It can take a while to get over a layoff when it’s unexpected, it isn’t so different than a relationship ending. We spend a lot of time at work and often put a lot of ourselves into our jobs.
This could be depression or just delayed grief as needing to find a job on short notice tends to block out a lot of emotion and it can take a bit after getting a job for that block to loosen.
What helps you get out of the funk and what helps someone else get out probably varies. For me a decent walk around the neighborhood/park and decreased phone time are/were very helpful. Even mild alcohol use was a very temporary thing that created a long-term detriment. Society sucks at teaching healthy coping mechanisms.
It isn’t but if it can’t work at that scale how do you convince anyone it will work when it’s larger scale? Showing feasibility is important.
Stack the court then sue Elon or any PAC.
Cling to power for 40ish years and realign the court as the conservatives die.
Impeachment and removal of corrupt justices, then sue.
1 and 3 are the only remotely realistic but I’m not that optimistic right now.
For a dude who used to be governor and had a personal superPAC for the race, basically got slapped in the face lol. Hahaha fuck Cuomo and Adams. Here’s to Zohran winning the general and actually getting stuff done!
Hey new nanoparticle just dropped. Wait, no its just lipids again lol.
Still cool, still just lipids.
I would really appreciate if this community at least included direct links to the primary scientific article before the media bullshit. https://pubs.acs.org/doi/10.1021/jacs.5c04123 And https://www.nature.com/articles/s41467-025-59136-z
Fudging chemists all about the synthesis very little on reasonable comparison (aav, or lentivirus).
Doesn’t have to be a straight relationship for “gifts” to turn into “you owe me”.
Thrush is just a name for the infection. Immunocompromised people can get oral thrush.
More openly than before with even less recourse.
A lot of it is laziness but on the other hand my boss will often cc me on irrelevant emails, rather infamously sometimes forward an entire 20 responses email chain and tell you to read it, and send 8 paragraphs of questions with only one related to me. Frankly, it is overwhelming and a waste of time. I’ve started not responding and my productivity and mental health have improved.
Emails and texts need to be succinct. The higher up the chain you go the more true this is. The higher up the chain the more emails you get think 200+. If someone writes a paragraph you’re skimming for relevance generally.
Tldr; professional communication does not need length. Justify your questions separately from actual bulleted or numbered questions.
As other have said Tinder was the biggest shift and the prime reason as stated is there’s a lot of fear that gets removed when you know you’re both there to date and you both at least superficially like each other.
This was before it was enshittified. Superlikes weren’t a thing, you had unlimited swipes and the algorithm tried to get you a match. Post-enshittification the algorithm tries to keep you hooked and paying. So there’s been a slight shift back to in-person but life is busy and expensive.
Shift happened well before 2019/2020.
Mmm I’m interested to see how the human trials go. It’s an interesting idea. Remove the sugars that block a conserved target so you generate antibodies to said conserved target. It’s odd to me that this works as well against wild virus that doesn’t have the sugars removed. Mechanistically, I’d assume the sugars still block that conserved target in wild virus so the antibodies targeting other less conserved parts are still doing the heavy lifting but then you wouldn’t have the cross recognition…idk.
Actual article. https://www.cell.com/cell/fulltext/S0092-8674(25)00210-7
Essentially they find that interleukin-6 (IL-6) a well-known inflammatory signal is important to neuronal lymphatics which are key to brain waste removal. Frankly, not too surprising imo but they do drill it down very well to what cells are effectors/affected. They use a drug, PLX5622, to inhibit this IL-6 activity and see significant improvement to mice where neuronal inflammation had been induced, genetically or surgically.
I’m very sleepy so didn’t read into any side-effects they notice or discuss as possibilities.
NY doesn’t have recall options in our state constitution. Unless someone can introduce him to Mario’s brother he’s there until 2026.
Yeah, late 90s early 00s gotta be honest I don’t remember much of the game. I remember enjoying it but whatever happened with Windows XP stopped my CDs from working on newer Windows.
Any recommendations?
They’re a cult, everyone within the cult implicitly agrees on the reality that matches what the leader(s) say regardless of what the leader does. There are many pipelines into the cult, gamers/incels, being an outcast for some reason, the general shitty state of things, etc they all lead to a desire for things to be better in some way. The leader promises this and everyone in the cult agrees that following the leader will fix these things somehow. If the leader does something contrary it is justified simply by saying that you as not the leader don’t understand. There’s 5d chess being played and while you’re awesome and good with 4d chess because you’re in the cult only the leader and some of the higher ups know the 5d strategy. Don’t worry and trust the leader. Drink the Flavor aid, your kids and friends already did.
Perfectly? In a language system different than your own. English to French/Spanish doesn’t require these sounds. English to like Thai or Chinese has a lot.
People learn new languages because you can get the ability back with training (hooray neurplasticity) but it is more difficult and takes longer.